a type of protein involved in regulating cellular processes including the ageing and death of cells and their resistance to stress: [as modifier] : sirtuin proteins promote longevity in many organisms.
Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation[8] and stress resistance, as well as energy efficiency and alertness during low-calorie situations.[9] Sirtuins can also control circadian clocks and mitochondrial biogenesis.