[ [ Ketoacidosis ] A pathological state marked by extreme state of metabolic ketosis. It decreases the pH of the blood which interferes with respiration by preventing haemoglobin from binding with oxygen, which can result in coma or death due to oxygen starvation. Diabetic ketoacidosis (DKA) occurs in type 1 diabetics when the liver overproduces ketone bodies in response to a More ]
A pathological state marked by extreme state of metabolic [ Ketosis ] A metabolic state of ketogenesis, where the liver produces ketone bodies as a supplementary energy source. It is characterised by blood concentrations of ketone bodies over 0.5 millimolar, and low levels of insulin and blood glucose, usually triggered by fasting or a dietary shortage of carbohydrates. Compare: Ketoacidosis More. It decreases the pH of the blood which interferes with respiration by preventing haemoglobin from binding with oxygen, which can result in coma or death due to oxygen starvation.
Diabetic ketoacidosis (DKA) occurs in type 1 diabetics when the liver overproduces [ Ketone Bodies ] The three water-soluble molecules, acetoacetic acid, beta-hydroxybutyric acid and acetone, that are produced during the metabolic state of ketosis. Ketone bodies are an important source of energy for the brain and heart during fasting or strenuous exercise. They are converted into acetyl-CoA which then enter the Krebs_cycle to produce ATP. The brain also converts acetyl-CoA into More in response to a shortage of insulin.
Alcoholic ketoacidosis results when alcohol causes dehydration, interfering with [ Gluconeogenesis ] The generation of glucose from non-carbohydrate substrates such as pyruvate, lactate, glycerol, and glucogenic amino acids. When there is a shortage of dietary carbohydrates, gluconeogenesis and glycogenolysis are the primary mechanisms for maintaining blood glucose levels. More and unchecked ketosis.
Ketoacidosis is considered a medical emergency and may be detected by the smell of [ Acetone ] An organic compound with a pungent floral or fruity odour. It is one of the three ketone bodies produced by the liver during the metabolic state of ketosis. Acetone is water-soluble, volatile and highly flammable. It has many commercial applications as an organic solvent and synthetic reagent. It is the active ingredient in nail polish remover and More on a person’s breath. Alcoholic ketoacidosis may be harder to detect due to the presence of alcohol on the breath.